CH3O2NU-Advanced Organic Chemistry ô€€– Contemporary Synthetic Methodology

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:6
Terms in which taught: Autumn term module
Pre-requisites:
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Current from: 2021/2

Module Convenor: Dr Chris Smith
Email: c.d.smith@reading.ac.uk

Type of module:

Summary module description:

The course aims to relate advanced topics in organic chemistry to topics covered in previous modules and provide a foundation of knowledge to enable a better understanding of the primary chemical literature.

Module Lead:ÌýÌýYan JiaoÌý(felixjiao@163.com)

Aims:

The course aims to relate advanced topics in organic chemistry to subject areas covered in previous modules and provide a foundation of knowledge to enable a better understanding of the primary chemical literature.

Assessable learning outcomes:

Students who have successfully completed this module will be able to:

• Describe the use of a variety of metal-based reagents in organic synthesis.


• Construct relatively complex organic molecules revealing synthetic strategies for target synthesis.


• Be able to describe the rules governing pericyclic reactions and outline their use in organic synthesis.

Additional outcomes:

Through the provision of lectures seminars and workshop students will develop a broader appreciation of the expansive nature of modern synthetic organic chemistry. The ability of each student to understand and apply this knowledge will be developed via a number of small group tutorials.

Outline content:

Week 1-3:

Advanced Organometallic Chemistry (8 lectures): Principles and special features of reactions catalysed by transition metal complexes. The course will focus on cyclisation reactions and the Suzuki, Heck and Stille reactions.

Workshop 2 lectures

Week 4-8:

Orbital Symmetry (10 lectures): Electrocyclisations, sigmatropic rearrangements, and cycload ditions. Frontier molecular orbital rules for stereochemical and regiochemical prediction.

Workshop 2 lectures

Seminar Ìý2 lectures, every student have chance to report their literature reading.

Week 9-11:

Heterocyclic Chemistry (8 lectures): Synthesis and reactions of pyrroles, furans, thiophenes, indoles, pyridines, quinolines and isoquino lines.

Workshop 2 lectures

Week12-16:

Advanced Organic Synthesis and Retrosynthetic Analysis (10 lectures): Strategies involved in the construction of complex natural products. The central role of the carbonyl group in retrosynthetic analysis will be reviewed. The synthesis of a range of structurally complex molecules will be described.

Workshop 2 lectures

Seminar Ìý2 lectures every student have chance to report their literature reading.

Brief description of teaching and learning methods:

Weekly lectures with two workshops on related material and seminars.